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        <h2 style="text-align: center;" class="art-PostHeader">
          Matura��o sexual precoce
        </h2>
        <span style="text-decoration: underline;"></span>
        <span class="content">�
          cl�ssico o
          conceito de que os
          caracteres sexuais secund�rios come�am a aparecer
          em
          torno dos 9 anos de idade, quando se admite ter in�cio a
          puberdade. Sabe-se, no entanto, que do ponto de vista hormonal, o
          per�odo de transi��o entre a
          inf�ncia e a
          puberdade surge antes, pela participa��o do eixo
          hipot�lamo-hipofis�rio. Nos �ltimos
          anos da
          inf�ncia, as gonadotrofinas secretadas pela
          hip�fise
          come�am a agir sobre os ov�rios, determinando o
          crescimento desordenado dos fol�culos, que passam a produzir
          estrog�nios. Estes horm�nios atuam sobre o
          �tero e
          sobre a mucosa vaginal, promovendo seu crescimento.<br>
          <br>
        </span><br>
        <div style="text-align: center;"><a href="../paginas/puberdade_precoce-imagem-1.html"><img
              style="border: 0px solid ; width: 126px; height: 240px;" alt="Clique para ampliar"
              title="Clique para ampliar" src="../img/478__320x240_478.jpg"></a><br>
        </div>
        <div style="text-align: center;">
          Lina Medina Menstruou aos 8 meses, engravidou antes dos 5 anos de
          idade
          e foi m�e com 5 anos e 8 meses<br>
        </div>
        <div style="text-align: center;"><a href="../paginas/puberdade_precoce-imagem-2.html"><img
              style="border: 0px solid ; width: 169px; height: 240px;" alt="Clique para ampliar"
              title="Clique para ampliar" src="../img/479__320x240_479.jpg"></a><br>
        </div>
        <p style="text-align: center;">Lina
          Medina, aos 7 anos,
          com seu filho,
          Geraldo Medina, com um ano de idade, junto com o m�dico que
          fez
          o parto (cesariana)</p>
        <p style="text-align: center;"><span class="content">
          </span></p>
        <p style="text-align: justify;"><span class="content">Matura��o
            sexual precoce, puberdade precoce ou precocidade sexual � o
            aparecimento dos caracteres sexuais secund�rios,
            acompanhados ou
            n�o de ovula��o, no per�odo
            da
            inf�ncia. Embora se admita que este per�odo
            termine aos 9
            anos, n�o deve causar grande
            preocupa��o o fato de
            os fen�menos puberais se manifestarem a partir dos 8 anos.</span></p>
        <p style="text-align: justify;">Alguns
          crit�rios podem ser
          admitidos para classificar a precocidade sexual:<br>
          1 � Aspectos neuro-end�crinos:<br>
          1.1 � Completa ou verdadeiro<br>
          1.2 � Incompleta ou pseudopuberdade precoce.</p>
        <p style="text-align: justify;">2-
          Quadro
          cl�nico e
          predomin�ncia de horm�nios:<br>
          2.1 � Isossexual<br>
          2.2 � Heterossexual<br>
        </p>
        <p style="text-align: justify;">3
          � Agente
          causador:<br>
          3.1 � Idiop�tica ou constitucional<br>
          3.2 � Org�nica</p>
        <p style="text-align: justify;">Apresentamos
          a seguir,
          alguns aspectos
          de cada variedade:</p>
        <p style="text-align: justify;">1.1
          � Completa
          ou verdadeira, se
          o sistema neuro-end�crino atinge a plenitude funcional e
          surge a
          ovula��o. � quadro raro, tendo como
          exemplo
          cl�ssico o caso da menina peruana Lina Medina que engravidou
          e
          deu � luz uma crian�a normal aos cinco anos de
          idade.</p>
        <p style="text-align: justify;">1.2
          � Incompleta
          ou
          pseudopuberdade precoce, se aparecerem alguns sinais de
          amadurecimento,
          mas n�o ocorre ovula��o.</p>
        <p style="text-align: justify;">2.1
          �
          Isossexual, quando
          predomina o horm�nio pr�prio do sexo oposto
          (androg�nio) e o quadro cl�nico se caracteriza por
          sinais
          de viriliza��o.</p>
        <p style="text-align: justify;">3.1
          �
          Idiop�tica ou
          constitucional, na qual a causa determinante n�o foi
          encontrada.</p>
        <p style="text-align: justify;">3.2
          �
          Org�nica, na qual se
          identifica a causa determinante.</p>
        <p style="text-align: justify;">As
          variedades de
          matura��o sexual precoce mais encontradas na
          cl�nica s�o: incompleta, isossexual e
          idiop�tica.</p>
        <p style="text-align: center;"><a href="../paginas/puberdade_precoce-imagem-3.html"><img
              style="border: 0px solid ; width: 156px; height: 240px;" alt="Clique para ampliar"
              title="Clique para ampliar" src="../img/480__320x240_480.jpg"></a><br>
        </p>
        <div style="text-align: center;">Telarca
          em
          crian�a de um ano e
          dez meses</div>
        <p style="text-align: center;"><a href="../paginas/puberdade_precoce-imagem-4.html"><img
              style="border: 0px solid ; width: 320px; height: 215px;" alt="Clique para ampliar"
              title="Clique para ampliar" src="../img/481__320x240_481.jpg"></a></p>
        Telarca em crian�a de dois anos e meio
        <p style="text-align: center;"></p>
        <p style="text-align: justify;"><span class="content"><strong>Causas<br>
            </strong><br>
            Na aprecia��o das causas da puberdade precoce,
            devem ser
            consideradas duas eventualidades: as variedades idiop�tica e
            org�nica. Para explicar a idiop�tica, invoca-se
            interfer�ncia do fator gen�tico. Quanto
            �
            org�nica, a origem se encontra em qualquer dos setores
            participantes do eixo neuro-end�crino. Abordaremos, a
            seguir, as
            poss�veis origens do quadro em quest�o.</span></p>
        <p style="text-align: justify;">Sistema
          nervoso central
          � as
          les�es intracranianas em desenvolvimento e as
          seq�elas de
          outras preexistentes agem sobre hipot�lamo, como fator
          irritativo. Este �rg�o, afetado por
          condi�es patol�gicas instaladas em
          estruturas
          vizinhas, as quais se encontra intimamente ligado, perde a capacidade
          de controlar a adeno-hip�fise. Esta passa a funcionar
          livremente
          e, produzindo gonadotrofinas, vai estimular os ov�rios e
          desencadear a precocidade sexual. Les�es
          p�s-inflamat�rias (seq�elas de
          encefalite), tumores
          intracranianos, hamartoma, hidrocefalia e traumas de parto,
          s�o
          referidos como causadores de matura��o sexual
          precoce.
          Segundo o conceito de Ruf, les�es encef�licas no
          per�odo perinatal ou na inf�ncia, destroem
          �reas
          nervosas que, no processo de recupera��o, vem a
          ser
          ocupadas por neur�nios adren�rgicos. Estes
          t�m a
          capacidade de crescer em qualquer per�odo da vida e, assim o
          fazendo, estimulam o eixo hipot�lamo-hipofis�rio,
          ocasionando a precocidade sexual. N�o somente as causas
          referidas, mas tamb�m os dist�rbios
          ps�quicos,
          podem antecipar o aparecimento da puberdade. Descrevem-se casos de
          oligofrenia associados � puberdade precoce.</p>
        <p style="text-align: justify;">Ov�rios
          � neoplasias
          funcionantes dos ov�rios, ocorrendo na inf�ncia,
          determinam a puberdade precoce. Tumor das c�lulas da
          granulosa e
          tecoma s�o neoplasias feminizantes que secretam
          estrog�nios, determinando puberdade precoce isossexual. Se o
          tumor � masculinizante, como por exemplo, o arrenoblastoma,
          a
          puberdade precoce ser� heterossexual, pela
          predomin�ncia
          do horm�nio heter�logo. Em casos excepcionais,
          outros
          tumores do ov�rio podem causar a
          matura��o sexual
          precoce: coriopitelioma ect�pico, disgerminoma e tumores
          embrion�rios.</p>
        <p style="text-align: justify;">Adrenais
          � nos
          casos de tumores e
          de hiperplasia adquirida da c�rtex da adrenal, ocorre
          precocidade heterossexual. Predomina o androg�nio e aparecem
          sinais de viriliza��o (figuras abaixo).</p>
        <p style="text-align: center;"><a href="../paginas/puberdade_precoce-imagem-5.html"><img
              style="border: 0px solid ; width: 149px; height: 240px;" alt="Clique para ampliar"
              title="Clique para ampliar" src="../img/482__320x240_482.jpg"></a><br>
        </p>
        <div style="text-align: center;">C�ncer
          de
          adrenal:
          desenvolvimento do t�rax e dos membros superiores da
          crian�a<br>
          <a href="../paginas/puberdade_precoce-imagem-6.html"><img style="border: 0px solid ; width: 320px; height: 211px;"
              alt="Clique para ampliar" title="Clique para ampliar" src="../img/483__320x240_483.jpg"></a></div>
        <p style="text-align: center;">C�ncer
          de
          adrenal: aspecto dos
          membros inferiores. Mesma crian�a da figura anterior</p>
        <p style="text-align: center;"><a href="../paginas/puberdade_precoce-imagem-7.html"><img
              style="border: 0px solid ; width: 320px; height: 210px;" alt="Clique para ampliar"
              title="Clique para ampliar" src="../img/484__320x240_484.jpg"></a></p>
        <p style="text-align: center;">C�ncer
          de
          adrenal: aspecto da
          vulva. Mesma crian�a da figura anterior</p>
        <p style="text-align: justify;">Tire�ide
          � do ponto de
          vista funcional, esta gl�ndula est� relacionada
          com os
          ov�rios. Encontram-se descritos casos de hipotireoidismo
          concomitantes a dist�rbios do amadurecimento genital.
          Admite-se,
          nestes casos, a participa��o ativa do
          hipot�lamo a
          qual, no entanto, ainda n�o se encontra bem esclarecida.</p>
        <p style="text-align: justify;"><strong>Outras
            origens<br>
          </strong><br>
        </p>
        <ol>
          <li> <span style="font-weight: bold;">Iatrog�nica</span>:
            sinais de precocidade sexual podem decorrer de
            administra��o de drogas para o tratamento de
            outras
            entidades patol�gicas. Estrog�nios, insulina e
            anabolizantes, t�m determinado desenvolvimento de caracteres
            sexuais secund�rios em crian�as.</li>
          <li><span style="font-weight: bold;">s�ndrome
              de McCune Albright</span>:
            oste�te fibrosa
            generalizada, acompanhada de hiperpigmenta��o
            cut�nea e de matura��o sexual precoce,
            constituem
            esta s�ndrome, descrita pela primeira vez em 1936. Embora
            les�es �sseas localizadas na base do
            cr�nio possam
            funcionar como fator irritativo do hipot�lamo,
            n�o existe
            explica��o convincente para os sinais da
            puberdade
            precoce que integram esta s�ndrome. Ademais, as radiografias
            do
            cr�nio nem sempre revelam oste�te fibrosa do
            cr�nio.</li>
          <li><span style="font-weight: bold;">infec�es
              cr�nicas</span>:
            tuberculose, s�filis
            e toxoplasma podem comprometer as meninges e serem
            respons�veis
            pela matura��o sexual precoce.</li>
        </ol>
        <p style="text-align: justify;"></p>
        <p style="text-align: justify;"><strong>Diagn�stico<br>
          </strong><br>
          As manifesta�es de puberdade sexual precoce mais
          comumente encontradas s�o: telarca e pubarca e perda
          sangu�nea genitais.</p>
        <p style="text-align: center;"><a href="../paginas/puberdade_precoce-imagem-8.html"><img
              style="border: 0px solid ; width: 156px; height: 240px;" alt="Clique para ampliar"
              title="Clique para ampliar" src="../img/485__320x240_485.jpg"></a></p>
        <p style="text-align: center;">Puberdade
          precoce: telarca
          em menina de
          cinco anos</p>
        <p style="text-align: center;"><a href="../paginas/puberdade_precoce-imagem-9.html"><img
              style="border: 0px solid ; width: 320px; height: 211px;" alt="Clique para ampliar"
              title="Clique para ampliar" src="../img/486__320x240_486.jpg"></a><br>
          Pubarca. Mesmo caso da figura anterior</p>
        <p style="text-align: center;"><a href="../paginas/puberdade_precoce-imagem-10.html"><img
              style="border: 0px solid ; width: 320px; height: 208px;" alt="Clique para ampliar"
              title="Clique para ampliar" src="../img/487__320x240_487.jpg"></a><br>
          Aspecto da pelve. Mesmo caso da figura anterior
        </p>
        <p style="text-align: center;"></p>
        <p style="text-align: justify;">A
          anamnese deve ser feita
          cuidadosamente, dedicando especial aten��o ao
          psiquismo
          da paciente e aos seus antecedentes familiares e pessoais. �
          importante apurar se outras pessoas da fam�lia apresentaram
          problema semelhante. Outro dado relevante relaciona-se com o tipo de
          parto que gerou a paciente: traumas obst�tricos podem
          originar
          les�es nervosas, respons�veis pela precocidade
          sexual. O
          exame f�sico geral deve focalizar, especialmente, os
          diversos
          aparelhos e as gl�ndulas de secre��o
          interna.</p>
        <p style="text-align: justify;"><span class="content">Os
            seguintes
            exames complementares integram o roteiro proped�utico:<br>
          </span></p>
        <ul>
          <li><span class="content">Radiografia de
              cr�nio para diagn�stico de tumores
              encef�licos e verificar o perfil da cela t�rcica.</span></li>
          <li><span class="content">Eletroencefalograma.</span></li>
          <li><span class="content">Dosagem de
              gonadotrofinas hipofis�rias.</span></li>
          <li><span class="content">Dosagem de
              estrog�nios.</span></li>
          <li><span class="content">Dosagem de 17 KS e 17 OH.</span></li>
          <li><span class="content">Colpocitologia hormonal.</span></li>
          <li><span class="content">Pregnosticon para
              detectar a produ��o de gonadotrofinas
              cori�nicas.</span></li>
          <li><span class="content">Ecografia da pelve.</span></li>
          <li><span class="content">Pneumopelvigrafia e/ou
              laparoscopia.</span></li>
          <li><span class="content">Bi�psia do
              endom�trio.</span></li>
          <li><span class="content">Provas funcionais da
              tire�ide das adrenais.</span></li>
          <li><span class="content">Provas de
              fun��o hep�tica.</span></li>
          <li><span class="content">Rea��o
              de Mantoux.</span></li>
          <li><span class="content">Rea�es
              e sorol�gicas para o diagn�stico
              de lues e de toxoplasmose.</span></li>
          <li><span class="content">Radiografia de
              m�os e punhos para determina��o
              da idade �ssea.</span></li>
        </ul>
        <p style="text-align: justify;"></p>
        <p style="text-align: justify;"><strong>Tratamento<br>
          </strong><br>
          Pacientes que apresentam puberdade precoce devem permanecer sob
          controle peri�dico. Seus pais devem ser
          instru�dos no
          sentido de prestar assist�ncia ao seu psiquismo de forma
          eficiente, por�m, sem alarde. O aparecimento dos caracteres
          sexuais secund�rios causa defasagem entre os
          desenvolvimentos
          som�tico e ps�quico. A mente infantil que, nestes
          casos,
          n�o acompanha o desenvolvimento f�sico, deve ser
          preservada de agravos.</p>
        <p style="text-align: justify;"><span class="content">Em
            todos os casos
            de matura��o sexual precoce, �
            importante
            controlar-se o crescimento, pois a a��o
            estrog�nica
            pode ocasionar soldura precoce das ep�fises
            �sseas. No
            intuito de evitar a parada do crescimento, empregam-se recursos
            terap�uticos para bloquear a a��o dos
            estrog�nios. Kupperman e Epstein, em 1962, recomendaram
            acetato
            de medroxiprogesterona, via intramuscular na dose de 100 mg de 14 em
            14
            dias. � prefer�vel a
            administra��o da mesma
            droga, via oral, na dose de 10 mg diariamente, em ciclos sucessivos
            de
            20 dias, com intervalo de dez dias entre um ciclo e outro. O tempo
            de
            tratamento obedece � rea��o das
            pacientes, e o
            controle de crescimento deve ser feito de 90 e 90 dias, pela medida
            da
            altura e pela radiografia de m�os e punhos. O tratamento de
            les�es do sistema nervoso central fica a cargo do
            neurologista
            ou do neurocirurgi�o. Nos casos de tumores dos
            ov�rios e
            das adrenais, a conduta � imposta pelo achado
            cir�rgico.
            Se o tumor � encapsulado e a cavidade peritonial se encontra
            livre de met�stases, executa se anexectomia unilateral,
            retirando-se a g�nada comprometida. Seguem-se exames
            ginecol�gicos peri�dicos, reoperando-se a
            paciente em
            termos radicais, ao menor sinal de recidiva.</span></p>
        <p style="text-align: justify;">Em
          caso de hiperplasia das
          adrenais, a
          terapia pelos cortic�ides est� indicada, por
          tempo
          indeterminado. Badbury recomenda come�ar com doses de 100 mg
          di�rios, at� se normalizarem de os
          n�veis de 17 KS
          urin�rios. Segue-se o tratamento de
          manuten��o em
          doses a serem estipuladas para cada caso. O horm�nio da
          tire�ide ser� empregado para corrigir casos de
          hipotireoidismo.</p>
        <p style="text-align: justify;"><span class="content">Se
            a causa for
            iatrog�nica, deve-se suspender a
            administra��o do
            agente causador. Tal medida susta o prosseguimento dos efeitos, mas
            n�o � poss�vel reverter a pubarca e a
            telarca
            eventualmente instaladas. A s�ndrome de McCune Albright
            �
            de tratamento complexo, requerendo cuidados com o sistema
            �sseo,
            para prevenir deformidades decorrentes da oste�te fibrosa
            generalizada. A tuberculose, a s�filis e a toxoplasmose
            ser�o corrigidas pelos tratamentos espec�ficos
            correspondentes</span></p>
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                  title="" style="color: rgb(0, 0, 0); text-decoration: none; font-size: 10px;"></a></div>
              <p style="margin: 0px 0px 12px;"><strong>&#1053;&#1072;&#1090;&#1082;&#1085;&#1091;&#1083;&#1089;&#1103; &#1089;&#1083;&#1091;&#1095;&#1072;&#1081;&#1085;&#1086; &#1085;&#1072; &#1042;&#1072;&#1096;
                  &#1073;&#1083;&#1086;&#1075;. &#1058;&#1077;&#1087;&#1077;&#1088;&#1100; &#1089;&#1090;&#1072;&#1085;&#1091; &#1087;&#1086;&#1089;&#1090;&#1086;&#1103;&#1085;&#1085;&#1086; &#1087;&#1088;&#1086;&#1089;&#1084;&#1072;&#1090;&#1088;&#1080;&#1074;&#1072;&#1090;&#1100;. &#1053;&#1072;&#1076;&#1077;&#1102;&#1089;&#1100;, &#1085;&#1077;
                  &#1088;&#1072;&#1079;&#1086;&#1095;&#1072;&#1088;&#1091;&#1077;&#1090;&#1077; &#1080; &#1076;&#1072;&#1083;&#1100;&#1096;&#1077; :)</strong></p>
              <p style="margin: 0px 0px 12px;">Tradu��o: Acidentalmente deparei
                com seu blog. Agora, irei analisar continuamente. Espero n�o
                estar decepcionado, e mais:)</p>
            </li>
            <li id="comment-2782" class="commentbody" style="color: rgb(0, 0, 0); font-size: 12px; list-style-type: none; margin: 0px 0px 10px; padding: 0px 5px; border: 1px solid rgb(0, 113, 156); background: rgb(255, 255, 255);">
              <div class="commenthead" style="color: rgb(0, 0, 0); padding: 5px 0px 10px; margin: 0px 0px 10px; border-bottom: 1px dashed rgb(0, 113, 156); background: rgb(255, 255, 255);"><img
                  alt="" src="http://1.gravatar.com/avatar/4911049f7a17d0fc426c47bf60a7856c?s=32&amp;d=identicon&amp;r=g"
                  srcset="http://1.gravatar.com/avatar/4911049f7a17d0fc426c47bf60a7856c?s=64&amp;d=identicon&amp;r=g 2x"
                  class="avatar avatar-32 photo" style="border: 0px; padding: 0px; float: left; margin: 0px 5px 0px 0px; background: rgb(255, 255, 255);"
                  width="32" height="32">
                <div class="commentcount" style="float: right; color: rgb(170, 170, 170); font-size: 20px; margin: 0px; padding: 5px 0px 0px; font-family: Georgia, Times, &quot;Times New Roman&quot;, serif;">2</div>
                <span class="authorlink" style="color: rgb(0, 0, 0); font-size: 12px; font-weight: bold; line-height: 1.5em;">Ontobevet</span>&nbsp;
                <span class=""></span><br>
                <a class="commentlink" href="http://cienciasdasaude.med.br/?p=1723#comment-2782"
                  title="" style="color: rgb(0, 0, 0); text-decoration: none; font-size: 10px;"></a></div>
              <p style="margin: 0px 0px 12px;">&#1044;&#1072;, &#1078;&#1072;&#1083;&#1100;, &#1095;&#1090;&#1086; &#1086;&#1073;&#1085;&#1086;&#1074;&#1083;&#1077;&#1085;&#1080;&#1103; &#1085;&#1072; &#1073;&#1083;&#1086;&#1075;&#1077;
                &#1087;&#1088;&#1086;&#1080;&#1089;&#1093;&#1086;&#1076;&#1103;&#1090; &#1085;&#1077; &#1090;&#1072;&#1082; &#1095;&#1072;&#1089;&#1090;&#1086;, &#1082;&#1072;&#1082; &#1093;&#1086;&#1090;&#1077;&#1083;&#1086;&#1089;&#1100; &#1073;&#1099;.</p>
              <p style="margin: 0px 0px 12px;">Tradu��o:<br>
                Sim, � uma pena que a atualiza��o para o blog n�o s�o tantas
                vezes quantas desejar.</p>
            </li>
            <li id="comment-2783" class="commentbody" style="color: rgb(0, 0, 0); font-size: 12px; list-style-type: none; margin: 0px 0px 10px; padding: 0px 5px; border: 1px solid rgb(0, 113, 156); background: rgb(255, 255, 255);">
              <div class="commenthead" style="color: rgb(0, 0, 0); padding: 5px 0px 10px; margin: 0px 0px 10px; border-bottom: 1px dashed rgb(0, 113, 156); background: rgb(255, 255, 255);"><img
                  alt="" src="http://0.gravatar.com/avatar/017024a92e5f40c73d936f086fda0a01?s=32&amp;d=identicon&amp;r=g"
                  srcset="http://0.gravatar.com/avatar/017024a92e5f40c73d936f086fda0a01?s=64&amp;d=identicon&amp;r=g 2x"
                  class="avatar avatar-32 photo" style="border: 0px; padding: 0px; float: left; margin: 0px 5px 0px 0px; background: rgb(255, 255, 255);"
                  width="32" height="32">
                <div class="commentcount" style="float: right; color: rgb(170, 170, 170); font-size: 20px; margin: 0px; padding: 5px 0px 0px; font-family: Georgia, Times, &quot;Times New Roman&quot;, serif;">3</div>
                <span class="authorlink" style="color: rgb(0, 0, 0); font-size: 12px; font-weight: bold; line-height: 1.5em;">iodittedo</span>&nbsp;
                <span class=""></span><br>
                <a class="commentlink" href="http://cienciasdasaude.med.br/?p=1723#comment-2783"
                  title="" style="color: rgb(0, 0, 0); text-decoration: none; font-size: 10px;"></a></div>
              <p style="margin: 0px 0px 12px;">&#1044;&#1091;&#1084;&#1072;&#1102;, &#1101;&#1090;&#1091; &#1090;&#1077;&#1084;&#1091; &#1084;&#1086;&#1078;&#1085;&#1086; &#1088;&#1072;&#1079;&#1074;&#1080;&#1074;&#1072;&#1090;&#1100;
                &#1076;&#1086; &#1073;&#1077;&#1089;&#1082;&#1086;&#1085;&#1077;&#1095;&#1085;&#1086;&#1089;&#1090;&#1080; :)</p>
              <p style="margin: 0px 0px 12px;">Tradu��o:<br>
                Penso que este tema pode ser desenvolvido at� ao infinito:)</p>
            </li>
            <li id="comment-2784" class="commentbody" style="color: rgb(0, 0, 0); font-size: 12px; list-style-type: none; margin: 0px 0px 10px; padding: 0px 5px; border: 1px solid rgb(0, 113, 156); background: rgb(255, 255, 255);">
              <div class="commenthead" style="color: rgb(0, 0, 0); padding: 5px 0px 10px; margin: 0px 0px 10px; border-bottom: 1px dashed rgb(0, 113, 156); background: rgb(255, 255, 255);"><img
                  alt="" src="http://2.gravatar.com/avatar/5d39448669c9e36b2a59e4f8d2ceded7?s=32&amp;d=identicon&amp;r=g"
                  srcset="http://2.gravatar.com/avatar/5d39448669c9e36b2a59e4f8d2ceded7?s=64&amp;d=identicon&amp;r=g 2x"
                  class="avatar avatar-32 photo" style="border: 0px; padding: 0px; float: left; margin: 0px 5px 0px 0px; background: rgb(255, 255, 255);"
                  width="32" height="32">
                <div class="commentcount" style="float: right; color: rgb(170, 170, 170); font-size: 20px; margin: 0px; padding: 5px 0px 0px; font-family: Georgia, Times, &quot;Times New Roman&quot;, serif;">4</div>
                <span class="authorlink" style="color: rgb(0, 0, 0); font-size: 12px; font-weight: bold; line-height: 1.5em;">Ngaras</span>&nbsp;
                <span class=""></span><br>
                <a class="commentlink" href="http://cienciasdasaude.med.br/?p=1723#comment-2784"
                  title="" style="color: rgb(0, 0, 0); text-decoration: none; font-size: 10px;"></a></div>
              <p style="margin: 0px 0px 12px;">&#1042; &#1087;&#1088;&#1080;&#1085;&#1094;&#1080;&#1087;&#1077; &#1074;&#1089;&#1077; &#1091;&#1089;&#1090;&#1088;&#1072;&#1080;&#1074;&#1072;&#1077;&#1090;, &#1085;&#1072;&#1096;&#1077;&#1083;
                &#1087;&#1086;&#1095;&#1090;&#1080; &#1074;&#1089;&#1077; &#1095;&#1090;&#1086; &#1093;&#1086;&#1090;&#1077;&#1083;.</p>
            </li>
            <li id="comment-2785" class="commentbody" style="color: rgb(0, 0, 0); font-size: 12px; list-style-type: none; margin: 0px 0px 10px; padding: 0px 5px; border: 1px solid rgb(0, 113, 156); background: rgb(255, 255, 255);">
              <div class="commenthead" style="color: rgb(0, 0, 0); padding: 5px 0px 10px; margin: 0px 0px 10px; border-bottom: 1px dashed rgb(0, 113, 156); background: rgb(255, 255, 255);"><img
                  alt="" src="http://0.gravatar.com/avatar/c62261f22c33cd865483487ed6c6f7b9?s=32&amp;d=identicon&amp;r=g"
                  srcset="http://0.gravatar.com/avatar/c62261f22c33cd865483487ed6c6f7b9?s=64&amp;d=identicon&amp;r=g 2x"
                  class="avatar avatar-32 photo" style="border: 0px; padding: 0px; float: left; margin: 0px 5px 0px 0px; background: rgb(255, 255, 255);"
                  width="32" height="32">
                <div class="commentcount" style="float: right; color: rgb(170, 170, 170); font-size: 20px; margin: 0px; padding: 5px 0px 0px; font-family: Georgia, Times, &quot;Times New Roman&quot;, serif;">5</div>
                <span class="authorlink" style="color: rgb(0, 0, 0); font-size: 12px; font-weight: bold; line-height: 1.5em;">astessymync</span>&nbsp;
                <span class=""></span><br>
                <a class="commentlink" href="http://cienciasdasaude.med.br/?p=1723#comment-2785"
                  title="" style="color: rgb(0, 0, 0); text-decoration: none; font-size: 10px;"></a></div>
              <p style="margin: 0px 0px 12px;">&#1047;&#1072;&#1085;&#1103;&#1090;&#1085;&#1086;-&#1079;&#1072;&#1085;&#1103;&#1090;&#1085;&#1086;, &#1085;&#1080;&#1075;&#1076;&#1077; &#1079;&#1072;&#1088;&#1072;&#1085;&#1077;&#1077; &#1085;&#1072;
                &#1090;&#1072;&#1082;&#1086;&#1077; &#1085;&#1077; &#1085;&#1072;&#1090;&#1099;&#1082;&#1072;&#1083;&#1089;&#1103;.</p>
            </li>
          </ol>
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