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<!DOCTYPE html PUBLIC "-//W3C//DTD HTML 4.01 Transitional//EN">
<html>
<head>
  <meta http-equiv="content-type"
 content="text/html; charset="UTF-8">
  <title>Caso 6: NIC III com
secre&ccedil;&atilde;o de muco</title>
  <link rel="stylesheet" href="estilo5.css" type="text/css"
 media="screen">
</head>
<body>
<div id="container">
<div id="header" title="sitename">
<h1 style="text-align: center;"><img
 style="width: 800px; height: 120px;" alt="" src="logo.jpg"></h1>
</div>
<div class="blogentry">
<div style="text-align: center;"><iframe src="indice.html"
 frameborder="0" height="20" width="800"></iframe></div>
<center><font class="option" color="#000000"><b><br>
</b></font></center>
<br>
<h2 class="art-PostHeader">Caso
6: NIC III com
secre&ccedil;&atilde;o
de muco</h2>
<h2 style="font-weight: normal; text-align: justify;"
 class="art-PostHeader"><small><small>
(cortesia:
Dr. C. M. Stanbridge
e Dr. C. H. Buckey)
</small></small></h2>
<div class="art-PostMetadataHeader">
<div class="art-PostHeaderIcons art-metadata-icons"><a
 href="http://www.cienciasdasaude.org/portal/?author=1"
 title="Posts de heinz" rel="author"><br>
</a>
</div>
</div>
<p style="text-align: center;"><span id="more-2554"></span>
<a href="../paginas/caso_6a-imagem-1.html" title=""
 class="shutterset_singlepic426"><img
 style="border: 0px solid ; width: 320px; height: 229px;"
 class="ngg-singlepic ngg-center" src="../img/426__320x240_426_JPG.jpg"
 alt="Clique para ampliar" title="Clique para ampliar"></a></p>
<p style="text-align: justify;">426
<strong>C&eacute;lulas
discari&oacute;ticas indiferenciadas. </strong>Este
&eacute; um outro
exemplo de paciente que apresentou densos fragmentos
constitu&iacute;dos de c&eacute;lulas discari&oacute;ticas
indiferenciadas com n&uacute;cleos hipercrom&aacute;ticos. (x
80)</p>
<p style="text-align: center;">
<a href="../paginas/caso_6a-imagem-2.html" title=""
 class="shutterset_singlepic427"><img
 style="border: 0px solid ; width: 320px; height: 231px;"
 class="ngg-singlepic ngg-center" src="../img/427__320x240_427_JPG.jpg"
 alt="Clique para ampliar" title="Clique para ampliar"></a></p>
<p style="text-align: justify;">427
<strong>Discariose
severa. </strong>Em
outro lugar no esfrega&ccedil;o, as c&eacute;lulas
s&atilde;o vistas em
grupos frouxos permitindo fechar o estudo da morfologia. Os
n&uacute;cleos s&atilde;o hipercrom&aacute;ticos com um
padr&atilde;o
de cromatina granular. Em algumas c&eacute;lulas, as bordas
citoplasm&aacute;ticas est&atilde;o bem definidas, sugerindo
diferencia&ccedil;&atilde;o escamosa, enquanto em outras o
citoplasma
&eacute; floculado e h&aacute; uma sugest&atilde;o de
forma&ccedil;&atilde;o acinar. (x 160)</p>
<p style="text-align: center;">
<a href="../paginas/caso_6a-imagem-3.html" title=""
 class="shutterset_singlepic428"><img
 style="border: 0px solid ; width: 320px; height: 231px;"
 class="ngg-singlepic ngg-center" src="../img/428__320x240_428_JPG.jpg"
 alt="Clique para ampliar" title="Clique para ampliar"></a></p>
<p style="text-align: justify;">428
<strong>N&uacute;cleos
desnudos. </strong>Este
campo cont&eacute;m n&uacute;cleos desnudos, p&aacute;lidos
e grandes.
O padr&atilde;o de cromatina nuclear &eacute; ainda granular,
mas
nucl&eacute;olos proeminentes est&atilde;o presentes. (x 160)</p>
<p style="text-align: center;">
<a href="../paginas/caso_6a-imagem-4.html" title=""
 class="shutterset_singlepic429"><img
 style="border: 0px solid ; width: 320px; height: 234px;"
 class="ngg-singlepic ngg-center" src="../img/429__320x240_429_JPG.jpg"
 alt="Clique para ampliar" title="Clique para ampliar"></a></p>
<p style="text-align: justify;">429
<strong>N&uacute;cleos
desnudos. </strong>Em
aumento maior, pode-se ver que os nucl&eacute;olos s&atilde;o
vermelhos. As caracter&iacute;sticas histol&oacute;gicas
ilustradas
sugerem um componente escamoso e um glandular da les&atilde;o e a
possibilidade de um ou ambos destes serem invasivos, pode
n&atilde;o
estar exclu&iacute;da, (x 400)</p>
<p style="text-align: center;">
<a href="../paginas/caso_6a-imagem-5.html" title=""
 class="shutterset_singlepic430"><img
 style="border: 0px solid ; width: 320px; height: 229px;"
 class="ngg-singlepic ngg-center" src="../img/430__320x240_430_JPG.jpg"
 alt="Clique para ampliar" title="Clique para ampliar"></a></p>
<p style="text-align: justify;">430
<strong>NIC
III: cone
bi&oacute;psia. </strong>O
exame dos cortes convencionais do
cone
bi&oacute;psia mostrou NIC III com algum envolvimento glandular,
mas o
epit&eacute;lio colunar endocervical revestindo as criptas estava
normal. (H &amp; E, x 16)</p>
<p style="text-align: center;">
<a href="../paginas/caso_6a-imagem-6.html" title=""
 class="shutterset_singlepic431"><img
 style="border: 0px solid ; width: 320px; height: 232px;"
 class="ngg-singlepic ngg-center" src="../img/431__320x240_431_JPG.jpg"
 alt="Clique para ampliar" title="Clique para ampliar"></a></p>
<p style="text-align: justify;">431
<strong>NIC
III: cone
bi&oacute;psia. </strong>Este
campo mostra parte do corte em
aumento
maior. Notar as c&eacute;lulas celulares que ainda est&atilde;o
presentes na superf&iacute;cie da NIC III. (H &amp; E, x 80)</p>
<p style="text-align: center;">
<a href="../paginas/caso_6a-imagem-7.html" title=""
 class="shutterset_singlepic432"><img
 style="border: 0px solid ; width: 320px; height: 224px;"
 class="ngg-singlepic ngg-center" src="../img/432__320x240_432_JPG.jpg"
 alt="Clique para ampliar" title="Clique para ampliar"></a></p>
<p style="text-align: justify;">432
<strong>NIC
III: cone
bi&oacute;psia. </strong>Este
corte mostra a
transi&ccedil;&atilde;o
entre o epit&eacute;lio colunas normal e NIC III. Al&eacute;m
disto, a
colora&ccedil;&atilde;o &eacute; positiva para mucina nas
c&eacute;lulas colunares; esta tamb&eacute;m &eacute; vista
na
superf&iacute;cie do NIC e c&eacute;lulas isoladas na
profundidade do
epit&eacute;lio, mostram colora&ccedil;&atilde;o azul ou
rosa, (PAS
&ndash; Azul de Alcian, x 80)</p>
<p style="text-align: center;">
<a href="../paginas/caso_6a-imagem-8.html" title=""
 class="shutterset_singlepic433"><img
 style="border: 0px solid ; width: 320px; height: 225px;"
 class="ngg-singlepic ngg-center" src="../img/433__320x240_433_JPG.jpg"
 alt="Clique para ampliar" title="Clique para ampliar"></a></p>
<p style="text-align: justify;">433
<strong>NIC III
(mucina positiva):
cone bi&oacute;psia. </strong>As
c&eacute;lulas isoladas
coradas para
mucina s&atilde;o vistas mais claramente em aumento maior. Notar a
concentra&ccedil;&atilde;o na superf&iacute;cie laminal.
(PAS &ndash;
Azul de Alcian, x 160)</p>
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