__  __    __   __  _____      _            _          _____ _          _ _ 
 |  \/  |   \ \ / / |  __ \    (_)          | |        / ____| |        | | |
 | \  / |_ __\ V /  | |__) | __ ___   ____ _| |_ ___  | (___ | |__   ___| | |
 | |\/| | '__|> <   |  ___/ '__| \ \ / / _` | __/ _ \  \___ \| '_ \ / _ \ | |
 | |  | | |_ / . \  | |   | |  | |\ V / (_| | ||  __/  ____) | | | |  __/ | |
 |_|  |_|_(_)_/ \_\ |_|   |_|  |_| \_/ \__,_|\__\___| |_____/|_| |_|\___V 2.1
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<HTML>
<HEAD>
<META HTTP-EQUIV="Content-Type" CONTENT="text/html; charset=windows-1252">
<META NAME="Generator" CONTENT="Microsoft Word 97">
<TITLE>ANTAGONISTA DA SEROTONINA</TITLE>
<META NAME="Template" CONTENT="C:\Arquivos de programas\Microsoft Office\Office\html.dot">
</HEAD>
<BODY LINK="#0000ff" VLINK="#800080" BACKGROUND="../images/fundo1.jpg">

<P><HR></P>
<B><U><P ALIGN="CENTER">[</B></U><A HREF="#_Toc448832430">ANTAGONISTA DA SEROTONINA</A><B><U>]</P>
</U><P ALIGN="CENTER">[</B><A HREF="#_Toc448832431">CONCEITO</A><B>]</P>
<P ALIGN="CENTER">[</B><A HREF="#_Toc448832432">DROGAS PRINCIPAIS</A><B>]</P>
</B><P ALIGN="CENTER">[<A HREF="#_Toc448832433">GRANISETRONA</A>] [<A HREF="#_Toc448832434">ONDANSETRON</A>]</P>
<P><HR></P>
<B><FONT FACE="Arial" SIZE=4><P ALIGN="CENTER"><A NAME="_Toc448832430">ANTAGONISTA DA SEROTONINA</A></P>
</B></FONT><FONT SIZE=2><P>&nbsp;</P>
</FONT><B><I><FONT FACE="Arial"><P ALIGN="CENTER"><A NAME="_Toc448832431">CONCEITO</A></P>

<UL>
</I></FONT><LI>CONCEITO(S):</LI></UL>

</B><P>Drogas ou medicamentos utilizados para impedir a liga&ccedil;&atilde;o da serotonina com seu receptor serotonin&eacute;rgico espec&iacute;fico da motilidade g&aacute;strica, produzindo efeito antiem&eacute;tico (contra v&ocirc;mitos). </P>
<P>Poder-se-ia perguntar porque n&atilde;o se utiliza a METOCLOPRAMIDA, mas em alguns casos, como nos tratamentos quimioter&aacute;picos antineoplasiantes (contra o c&acirc;ncer), a metoclopramida n&atilde;o resolve e at&eacute; pode piorar o quadro do paciente devido aos seus efeitos adversos.</P>
<P>&nbsp;</P>
<B><I><FONT FACE="Arial"><P ALIGN="CENTER"><A NAME="_Toc448832432">DROGAS PRINCIPAIS</A></P>
</B></I></FONT><P>&nbsp;</P>
<FONT FACE="Arial" COLOR="#ff0000"><P ALIGN="CENTER"><A NAME="_Toc448832433"><A NAME="_Toc448830996">GRANISETRONA</A></A></P>

<UL>
</FONT><B><LI>NOME(S) COMERCIAL(IS): </B>KYTRILL </LI>
<B><LI>Indica&ccedil;&otilde;es:</LI></UL>

</B><P>Antiem&eacute;tico; antagonista dos receptores da serotonina no tratamento das n&aacute;useas e v&ocirc;mitos induzidos por terapia citost&aacute;tica em paciente com neoplasia (preven&ccedil;&atilde;o e tratamento).</P>

<UL>
<B><LI>N&atilde;o deve ser administrado em:</LI></UL>

</B><P>Crian&ccedil;a (menor de 2 anos); hipersensibilidade &agrave; granisetrona.</P>

<UL>
<B><LI>Deve ser administrado cautelosamente em:</LI></UL>
<DIR>

</B><P>Mulher amamentando; obstru&ccedil;&atilde;o intestinal.</P></DIR>


<UL>
<B><LI>Efeitos indesej&aacute;veis e/ou rea&ccedil;&otilde;es adversas:</LI></UL>
<DIR>

</B><P>Cefal&eacute;ia (dor de cabe&ccedil;a); constipa&ccedil;&atilde;o intestinal.</P></DIR>


<UL>
<B><LI>Cuidados importantes:</LI></UL>

</B><P>� ingerir alimentos ricos em fibras.</P>
<P>� tomar bastante l&iacute;quidos durante o tratamento.</P>

<UL>
<B><LI>Efeitos sobre os testes psicol&oacute;gicos: **DEPRESSOR**</LI></UL>

</B><P ALIGN="CENTER"><HR></P>
<FONT FACE="Arial" COLOR="#ff0000"><P ALIGN="CENTER"><A NAME="_Toc448832434"><A NAME="_Toc448830997">ONDANSETRON</A></A></P>

<UL>
</FONT><B><LI>NOME(S) COMERCIAL(IS): </B>MODIFICAL; ZOFRAN</LI></UL>

<P>Antiem&eacute;tico; antagonista dos receptores da serotonina indicado em n&aacute;usea e v&ocirc;mito induzidos por quimioterapia ou radioterapia; n&aacute;usea e v&ocirc;mito do p&oacute;s-operat&oacute;rio.</P>

<UL>
<B><LI>N&atilde;o deve ser administrado em:</LI></UL>

</B><P>Crian&ccedil;as menores de 4 anos. </P>

<UL>
<B><LI>Deve ser administrado cautelosamente em:</LI></UL>
<DIR>

</B><P>Insufici&ecirc;ncia hep&aacute;tica; insufici&ecirc;ncia renal; mulher amamentando.</P></DIR>


<UL>
<B><LI>Efeitos indesej&aacute;veis e/ou rea&ccedil;&otilde;es adversas:</LI></UL>

</B><P>Altera&ccedil;&atilde;o no eletrocardiograma (ECG); angina; estreitamento dos br&ocirc;nquios; constipa&ccedil;&atilde;o intestinal; convuls&atilde;o; diarr&eacute;ia; dor de cabe&ccedil;a; erup&ccedil;&atilde;o na pele; diminui&ccedil;&atilde;o do pot&aacute;ssio no sangue; rea&ccedil;&atilde;o de hipersensibilidade; sensa&ccedil;&atilde;o de calor ou rubor na cabe&ccedil;a e na boca do est&ocirc;mago; taquicardia.</P>

<UL>
<B><LI>Efeitos sobre os testes psicol&oacute;gicos: **DEPRESSOR**</LI></UL>
</B></BODY>
</HTML>

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