__  __    __   __  _____      _            _          _____ _          _ _ 
 |  \/  |   \ \ / / |  __ \    (_)          | |        / ____| |        | | |
 | \  / |_ __\ V /  | |__) | __ ___   ____ _| |_ ___  | (___ | |__   ___| | |
 | |\/| | '__|> <   |  ___/ '__| \ \ / / _` | __/ _ \  \___ \| '_ \ / _ \ | |
 | |  | | |_ / . \  | |   | |  | |\ V / (_| | ||  __/  ____) | | | |  __/ | |
 |_|  |_|_(_)_/ \_\ |_|   |_|  |_| \_/ \__,_|\__\___| |_____/|_| |_|\___V 2.1
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<!DOCTYPE html PUBLIC "-//W3C//DTD HTML 4.01 Transitional//EN">
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 content="text/html; charset="UTF-8">
  <title>Midazolam</title>
  <link rel="stylesheet" href="estilo5.css" type="text/css"
 media="screen">
</head>
<body>
<div id="container">
<div id="header" title="sitename">
<h1 style="text-align: center;"><img
 style="width: 800px; height: 120px;" alt="" src="logo.jpg"></h1>
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<h2 style="text-align: center;" class="art-PostHeader">Midazolam
</h2>
<div class="art-PostMetadataHeader">
<div class="art-PostHeaderIcons art-metadata-icons">C&oacute;digo
DCB:
1378.01-5</div>
</div>
<p style="text-align: justify;">O
QUE &Eacute;<br>
Diazep&iacute;nico de a&ccedil;&atilde;o curta, agonista do
receptor GABAA que se liga em uma subunidade do receptor e tem como
indica&ccedil;&atilde;o principal a
indu&ccedil;&atilde;o de anestesia, mas tamb&eacute;m
&eacute; eficaz nos quadros de espasmos provocados por tetanismo.</p>
<p style="text-align: justify;">RECOMENDA&Ccedil;&Atilde;O<br>
Administrar a 2mg/minuto quando por via endovenosa.
Administra&ccedil;&otilde;es r&aacute;pidas podem causar
depress&atilde;o respirat&oacute;ria importante.</p>
<p style="text-align: justify;">INTRA-VENOSA
EM
&ldquo;BOLO&rdquo;<br>
Sim.</p>
<p style="text-align: justify;">PERFUS&Atilde;O
INTERMITENTE<br>
Sim.</p>
<p style="text-align: justify;">INTRA-VENOSA
CONT&Iacute;NUA<br>
Sim.</p>
<p style="text-align: justify;">INTRAMUSCULAR<br>
Sim.</p>
<p style="text-align: justify;">Adultos:
de 0,07 a
0,1mg/kg de peso corporal.<br>
Crian&ccedil;as necessitam de doses proporcionalmente maiores que
os adultos e recomenda-se as seguintes: 0,15 a 0,20mg/kg, que devem ser
administradas entre 20 e 30 minutos antes da
indu&ccedil;&atilde;o da anestesia.</p>
<p style="text-align: justify;">SOLU&Ccedil;&Otilde;ES
COMPAT&Iacute;VEIS<br>
</p>
<ul style="text-align: justify;">
  <li>Cloreto de S&oacute;dio
0,9%</li>
  <li>Dextrose 5% em
&aacute;gua</li>
</ul>
<p style="text-align: justify;">ESTABILIDADE<br>
Midazolam na concentra&ccedil;&atilde;o 2mg/ml em cloreto de
s&oacute;dio 0,9%, em seringas de polipropileno, &eacute;
est&aacute;vel por at&eacute; 10 dias em temperaturas
inferiores &agrave; 30&ordm;C (Stiles et al, 1996). em
concentra&ccedil;&otilde;es de 0,5mg/ml em dextrose 5% em
&aacute;gua ou cloreto de s&oacute;dio 0,9%, em frasco
&acirc;mbar, apresenta estabilidade de at&eacute; 36 dias em
temperaturas entre 4 e 41&ordm;C (Pramar et al, 1997).</p>
<p style="text-align: justify;">OBSERVA&Ccedil;&Otilde;ES<br>
</p>
<ol style="text-align: justify;">
  <li>Em pacientes idosos com
danos cerebrais org&acirc;nicos
ou altera&ccedil;&otilde;es das fun&ccedil;&otilde;es
card&iacute;aca ou respirat&oacute;ria, deve-se determinar com
prud&ecirc;ncia a dose, avaliando as
condi&ccedil;&otilde;es especiais e individuais de cada
paciente.</li>
  <li>A
administra&ccedil;&atilde;o por via intravenosa
deve ser realizada lentamente, ou seja, aproximadamente 5mg em 10
segundos para a indu&ccedil;&atilde;o anest&eacute;sica e
1mg em 30 segundos para a seda&ccedil;&atilde;o basal. O efeito
da droga aparece em torno de 2 minutos ap&oacute;s o
in&iacute;cio da inje&ccedil;&atilde;o.</li>
  <li>Dosagens para uso oral em
crian&ccedil;as:</li>
</ol>
<div style="text-align: center;"><img
 style="width: 371px; height: 225px;" alt=""
 src="../img/tabela_midazolan.jpg"></div>
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